• 9:00 - 9:45 AM
  Strategies for Vaccine Development.
  Frank Plummer, National Microbiology Laboratory, Winnipeg, MB
  
  
• 9:45 AM - 10:30 AM
  Novel Strategies for Improving the Immune Response Induced by DNA Vaccines for HIV.
  David Weiner, University of Pennsylvania, PA, USA

• 11:00 - 11:45 AM
  Pathogenic e. coli- role of the pathogen, host, and microbiota.
  Bret Finlay, University of British Columbia, Vancouver, BC
  
  
• 11:45 AM - 12:30 PM
  ER-mediated phagocytosis of Leishmania parasites in neutrophils.
  Michel Desjardins, University of Montreal, Montreal, QC
  
  

Minisymposia will include a 30 minute talk by the Minisymposium Chair followed by shorter presentations selected from submitted abstracts

Minisymposium II

Parasitic infection and immunity

2:30 - 3:00 PM
Vaccine development
Chair: Lorne Babiuk, VIDO, Saskatoon, SK

3:00 - 3:20PM
M13 - PRIMING WITH DNA ENCODING E2 AND BOOSTING WITH E2 PROTEIN FORMULATED WITH CPG OLIGODEOXYNUCLEOTIDES INDUCES STRONG IMMUNE RESPONSES AND PROTECTION FROM BOVINE VIRAL DIARRHEA VIRUS TYPE 2 IN CATTLE.

R. Liang, J.V. van den Hurk, A. Landi, D. Deregt, L.A. Babiuk and S. van Drunen Littel-van den Hurk, Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Canada.

3:20 – 3:40 PM
M14 - NOVEL PLANT VIRUS-BASED VACCINE INDUCES PROTECTIVE CTL MEDIATED IMMUNITY THROUGH EFFICIENT DENDRITIC CELL MATURATION.

Patrick Lacasse*, Jérôme Denis†, Réjean Lapointe‡, Denis Leclerc† et Alain Lamarre* * Immunovirology Laboratory, INRS-Institut Armand-Frappier, Laval, Qc, Canada. † Centre de Recherche en Infectiologie, Pavillon CHUL, Université Laval, Québec, Qc, Canada ‡ Centre de Recherche, CHUM, Hôpital Notre-Dame, Université de Montréal and Institut du Cancer de Montréal, Montréal, Qc, Canada.

3:40 – 4:00 PM
M15 - SIGNIFICANT ENHANCEMENT OF SPECIFIC CELLULAR IMMUNE RESPONSE BUT SUBSTANTIAL SUPPRESSION OF MUCOSAL ANTIBODY RESPONSES IN BALB/C MICE ADMINISTRATED WITH ADENOVIRUS TARGETED TO CD40 (+) CELLS.

Caroline Gravel1, Deqi Huang1, Alexander V Pereboev2, Nikolay Korokhov2, Runtao He3, Bozena Jaentschke1, Louise Larocque1, William Casley1, Michelle Lemieux1, David T. Curiel2, Wanxue Chen4 and Xuguang Li1,5 1. Centre for Biologics Research, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, ON, Canada 2. Gene Therapy Centre, University of Alabama at Birmingham, Birmingham, AL, USA 3. National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada 4. National Research Council, Ottawa, On, Canada 5. Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, On, Canada.

4:30 – 4: 50 PM
M16 - IMMUNOGENICITY OF A GIARDIA LAMBLIA TRANSMISSION-BLOCKING DNA VACCINE DELIVERED BY SALMONELLA TYPHIMURIUM (STM1 STRAIN) TO THE INTESTINAL MUCOSAL IMMUNE SYSTEM.

Aws Abdul-Wahid and G. Faubert. Institute of Parasitology, McGill University, Ste-Anne-de-Bellevue, Canada.

4:50 – 5:10 PM
M17 - ANTI-APOPTOTIC MOLECULE M11L ENHANCES IMMUNOGENICITY OF HIV DNA VACCINE IN MICE.

Jin Su, Grant McFadden and Gregory Dekaban, BioTherapeutics Research Group, Robarts Research Institute, London, ON, Canada.

5:10- 5:30 PM
M18 - CONSIDERATIONS IN VACCINE DRUG DEVELOPMENT FOR PRE-MARKET REGULATORY REQUIREMENTS.

Harold Rode, Centre for Biologics Evaluation, Biologics and Genetic Therapies Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ontario.

2:30 - 3:00 PM
Cytokines and viruses: signaling for supremacy.
Chair: Eleanor Fish, University of Toronto, Toronto, ON

3:00 – 3:20 PM
M19 - GAMMA-CHAIN RECEPTOR CYTOKINES DOWN-REGULATE IL-7 RECEPTOR-ALPHA (CD127) EXPRESS-ION ON CD8+ T-CELLS AND DIFFERENTIALLY AFFECT CELL CYCLING OF ACTIVATED CD8+CD127+ AND CD8+CD127- CELLS.

Crawley AM., Katz T., Parato K., Angel JB. Ottawa Health Research Institute, Ottawa, Ontario. CANADA.

3:20 – 3:40 PM
M20 - THE ABILITY OF VERO CELLS TO DIFFERENTIALLY RESPOND TO VIRUS-DERIVED STIMULI DEPENDS ON PROTEIN ABUNDANCE AND A NOVEL CELLULAR COMPONENT.

Tracy Chew, Meaghan Hancock, and Karen L. Mossman, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

3:40 – 4:00 PM
M21 - CHARACTERIZATION OF INTRACELLULAR SIGNALLING COMPONENTS INVOLVED IN SEPSIS.

Tyler Kirwan, Danielle Brabant, Paul Michael, Marisa Tessier, Marija Tonnos, Shuhung Kung, Abdelwahab Omri, Chilakamarti V. Ramana, Anand Kumar, Joseph E. Parrillo and Aseem Kumar, Department of Chemistry and Biochemistry and the Biomolecular Sciences Programme, Laurentian University, Sudbury, ON, Canada.

4:30 – 4:50 PM
M22 - HUMAN SEPTIC SERA INDUCES DEATH RECEPTOR MEDIATED APOPTOSIS IN HUMAN FIBROBLASTS.

Danielle Brabant, Paul Michael, Marija Tonnos, Marisa Tessier, Shuhung Kung, Tyler Kirwan, Abdelwahab Omri, Chilakamarti V. Ramana, Joseph E. Parrillo, Anand Kumar and Aseem Kumar, Department of Chemistry and Biochemistry and the Biomolecular Sciences Programme, Laurentian University, Sudbury, ON, Canada.

4:50 - 5:10 PM
M23 - STUDY OF THE SUSCEPTIBILITY OF TWO INBRED MOUSE STRAINS TO STREPTOCOCCUS SUIS SEROTYPE 2 INFECTION.

Maria de la Cruz Dominguez-Punaro1, Mariela Segura2, Danuta Radzioch 2, Serge Rivest 3 and Marcelo Gottschalk1. 1GREMIP/CRIP, Faculté médecine vétérinaire, Université de Montréal, St-Hyacinthe, QC 2McGill University Health Centre Research Institute, Montréal, QC 3Laboratory Molecular Endocrinology, CHUL, St-Foy, QC.

5:10 – 5:30 PM
M24 - LIGHT IS CRITICAL FOR IL-12 PRODUCTION BY ANTIGEN PRESENTING CELLS, TH1 CELL DEVELOPMENT AND RESISTANCE TO LEISHMANIA MAJOR.

Guilian Xu, Dong Liu, Ifeoma Okwor, Sam Kung, YangXin Fu* and Jude E Uzonna, Department of Immunology, University of Manitoba, Winnipeg, *Department of Pathology, University of Chicago, IL, USA. Source of Research Funds: CIHR and MHRC.

2:30 - 3:00 PM
The sensing of the commensal intestinal microbiota and immunological adaptation at the mucosal surface.
Chair: Andrew Macpherson, McMaster University, Hamilton, ON

3:00 – 3:20 PM
M25 - PATHOGEN SEGREGATION WITHIN PHAGOSOMES RESTRICTS CD8+ T CELL ACTIVATION: A MECHANISM OF IMMUNE EVASION.

Subash Sad, Rachel Luu, K. Gurnani, H. van Faassen, R. Dudani and L. Krishnan. Institute for Biological Sciences, NRC, Ottawa, Ontario, Canada. Source of Research Funds: CIHR and NRC.

3:20 – 3:40 PM
M26 - PREGNANCY IMPAIRS THE INNATE IMMUNE RESPONSE TO SALMONELLA TYPHIMURIUM LEAD-ING TO RAPID FATAL INFECTION.

Lakshmi Krishnan†, Branka Pejcic-Karapetrovic*†, Brett B Finlay‡ and Subash Sad†; †Department of Biochemistry, Microbiology and Immunology, University of Ottawa, and Institute for Biological Sciences, National Research Council of Canada, Ottawa, ON. ‡Michael Smith Laoratories, University of British Columbia, Vancouver, BC, Canada. Source of Research Funds: National Research Council and Canadian Institute for Health Research.

3:40 – 4:00 PM
M27 - A ROLE FOR TOLL-IL-1 RECEPTOR DOMAIN-CONTAINING ADAPTER-INDUCING IFN-? IN THE HOST DEFENSE AGAINST PSEUDO-MONAS AERUGINOSA LUNG INFECT-ION.

Melanie R. Power, Bo Li, and Tong-Jun Lin, Department of Microbiology and Immunology, Dalhousie University, Halifax, NS. Source of Research Funds: Canadian Institutes of Health Research, Canadian Cystic Fibrosis Foundation and IWK Health Center.

4:30 - 4:50 PM
M28 - A SPECIFIC INNATE IMMUNE RECEPTOR ORCHESTRATES THE CAPTURE AND KILLING OF PATHOGENIC NEISSERIA BY HUMAN NEUTROPHILS.

Helen Sarantis* and Scott D. Gray-Owen* Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario. Source of Research Funds: CIHR, OGS.

Annie Bibeau-Poirier*, Simon-Pierre Gravel*, Jean-François Clément*, Sébastien Rolland*, Geneviève Rodier**, Philippe Coulombe**, John Hiscott§, Nathalie Grandvaux‡, Sylvain Meloche** and Marc. J. Servant*; *Faculty of Pharmacy, **Institute of Research in Immunology and Cancer, ‡Centre Hospitalier de l’Université de Montréal and Department of Biochemistry, University of Montreal, Montreal, Canada and §Lady Davis Institute for Medical Research, McGill University, Montreal, Canada. Source of Research Funds: CIHR/FRSQ.

3:20 – 3:40 PM
M30 - FUSION AND CLEAVAGE OF PARAMYXOVIRUS FUSION PROTEIN IS DIRECTLY RELATED TO 6-HELIX BUNDLE STABILITY.

Neil McKenna*(1), Sharon Ebata(1), Christine Grise(1), Bogna Zolkiewska(1), Mark A. Wurth(2), Rebecca Ellis Dutch(2), and Ken Dimock(1). (1) Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada; (2) Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington.

3:40 – 4:00 PM
M31 - ANTIVIRAL EFFECT OF AURINTRICARBOXYLIC ACID (ATA) ON SARS CORONAVIRUS (SARS-COV), WEST NILE VIRUS (WNV), AND DENGUE (DEN) VIRUS IN VITRO.

Maya Andonova, Runtao He, Anton Andonov, Jingxin Cao, Todd Cutts, Elsie Grudesky, Jody Berry, Yvon Deschambault, Michael Drebot; National Microbiology Laboratory, PPHB, Winnipeg, Manitoba.

4:30 – 4:50 PM
M32 - THE SR-RICH DOMAIN IN SARS_COV NUCLEOCAPSID PROTEIN IS IMPORTANT FOR THE REPLICATION OF THE VIRUS.

Shaun Tyler, Anton Andonov, Todd Cutts, Jingxin Cao, Elsey Grudesky, Gary Van Domselaar, Jody Berry Sean Li and Runtao He. National Microbiology Laboratory, PPHB, Winnipeg, Manitoba.

4:50 – 5:10 PM
M33 - EVOLUTION OF INTERFERON RESISTANCE IN THE INFLUENZA A VIRUS NS1 GENE.

Earl Brown*, Yishan Li*, Liya Keleta*, Song Liu*, Tom Arnason*, and Yu-Wen Hu*. Dept. of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Source of Research Funds: Canadian Institutes of Health Research.