(Posted: September 26, 2006)

Wednesday, October 11, 2006
2:30 - 5:50 PM
Capital Hall, Room B

Minisymposium I:

2:30 - 3:00 PM
Protein interactions at the bacterial cell surface.
Chair: James Coulton, McGill University, Montreal, QC

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3:00 – 3:20 PM
M01 - MEASUREMENT OF VIRULENCE PROMOTER ACTIVITY IN ENTERO-AGGREGATIVE E. COLI BY IN VIVO IMAGING.

Chelsea Tirling1, Nick Morin2, James Nataro2 and Theodore Steiner3, 1University of Victoria, 2University of Maryland, 3University of British Columbia.

3:20 – 3:40 PM
M02 - ELUCIDATION OF THE CMP-PSEUDAMINIC ACID PATHWAY ESSENTIAL FOR HELICOBACTER PYLORI MOTILITY AND COLONIZAT-ION.

Ian Schoenhofen§, David McNally§, Susan Logan§, Jean-Robert Brisson§, Miroslaw Cygler?, and Allan Matte?, §NRC, Institute for Biological Sciences, Ottawa, Ontario, Canada, NRC, Biotechnology Research Institute, Montreal, Quebec, Canada.

3:40 – 4:00 PM
M03 - THE MULTIPLE FLAGELLINS OF CLOSTRIDIUM BOTULINUM: GENE AND POSTTRANSLATIONAL MODIFICATION DIVERSITY.

Catherine Paul1,2, Susan Twine2, Kevin Tam1, James Mullen2, John Kelly2, John Austin1, and Susan Logan2 : 1Bureau of Microbial Hazards, HFPB, Health Canada, Ottawa, ON, Can.; 2Institute for Biological Sciences, National Research Council, Ottawa, ON, Can.

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4:30 – 4:50 PM
M04 - PROBING THE PROTEOMES OF PATHOGENIC E. COLI USING X-RAY CRYSTALLOGRAPHY.

Allan Matte1, Erumbi S. Rangarajan2, Eunice Ajamian2, Christine Munger2, Rong Shi2, John Wagner1, Yunge Li1, Joseph D. Schrag1, Ming-ni Hung1, Ante Tocilj2, Stephane Raymond1 and Miroslaw Cygler1,2; 1Biotechnology Research Institute, Montreal, QC, Canada, 2Department of Biochemistry, McGill University, Montreal QC Canada.


4:50 – 5:10 PM
M05 - FLAGELLAR GLYCOSYLATION OF CLOSTRIDIUM DIFFICILE – A NOVEL TARGET FOR ANTI-INFECTIVES?

Susan Logan, Susan Twine, Annie Aubry, Ian Schoenhofen, Michael Reith^, and John Kelly Institute for Biological Sciences, National Research Council, Ottawa, Ontario, Canada ^Institute for Marine Biosciences, National Research Council, Ottawa, Ontario, Canada.

5:10 – 5:30 PM
M06 - INACTIVATION OF RAB7 BY A MYCOBACTERIAL GAP-LIKE ACTIVITY CONTRIBUTES TO ARREST OF MYCOBACTERIAL PHAGOSOME MATURATION.

Sun J, Hong T, Soualhine H, Deghmane AE, Bucci C, Solodkin A and Hmama Z. Division of Infectious Diseases, University of British Columbia, Vancouver, Canada and Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Universita degli Studi di Lecce, Lecce, Italy.

5:30 – 5:50 PM
M07 - INTERACTIONS BETWEEN TonB FROM ESCHERICHIA COLI AND THE PERIPLASMIC PROTEIN FhuD.

David Carter, McGill University, Montreal, QC

2:30 - 3:00 PM
PPARy AGONISTS CONFER PROTECTION TO EXPERIMENTAL CEREBRAL MALARIA AND IMPROVE OUTCOME IN PLASMODIUM FALCIPARUM MALARIA IN A RANDOMIZED CONTROLLED TRIAL.

Chair: Kevin Kain, University of Toronto,
Toronto, ON

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3:00 – 3:20 PM
M08 - CHARACTERIZATION OF THE LOCAL IMMUNE RESPONSE TO CYST ANTIGENS DURING THE ACUTE AND ELIMINATION PHASES OF MURINE GIARDIASIS.

Aws Abdul-Wahid and G. Faubert. Institute of Parasitology, McGill University, Ste-Anne-de-Bellevue, Canada.

3:20 - 3:40 PM
M09 - HIV IMPAIRS OPSONIC PHAGOCYTIC CLEARANCE OF PREGNANCY-ASSOCIATED MALARIA PARASITES.

Lena Serghides, Jessica Keen, Kodjo Ayi, Samir N. Patel, and Kevin C. Kain. Faculty of Medicine, University of Toronto; McLaughlin-Rotman Centre, McLaughlin Center for Molecular Medicine, UHN and University of Toronto, Canada.

3:40 – 4:00 PM
M10 - ENHANCED RESISTANCE TO LEISHMANIA MAJOR DESPITE DRAMATIC IMPAIRED TH1 RESPONSE IN PI3K-DEFICIENT MICE.

Dong Liu, Klaus Okkenhaug*, Bart Vanhaesebroeck*, Jude E. Uzonna, Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada, *Ludwig Institute for Cancer Research, London, UK.

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4:30 – 4:50 PM
M11 - LOSS OF ESTABLISHED INFECTION-INDUCED RESISTANCE FOLLOWING VACCINATION WITH KILLED LEISHMANIA PARASITES: IMPLICATIONS FOR VACCINE DESIGNS AND VACCINATION STRATEGIES.

Ifeoma Okwor, Dong Liu and Jude Uzonna, Department of Immunology, University of Manitoba Winnipeg, MB.

4:50 – 5:10 PM
M12 - STRUCTURAL GENOMICS AS AN ENABLING TOOL FOR PROTOZOAN DRUG DISCOVERY AND VACCINE DEVELOPMENT.

Raymond Hui, Structural Genomics Consortium University if Toronto.

2:30 - 3:00 PM
Vaccine development
Chair: Lorne Babiuk, VIDO, Saskatoon, SK

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3:00 - 3:20PM
M13 - PRIMING WITH DNA ENCODING E2 AND BOOSTING WITH E2 PROTEIN FORMULATED WITH CPG OLIGODEOXYNUCLEOTIDES INDUCES STRONG IMMUNE RESPONSES AND PROTECTION FROM BOVINE VIRAL DIARRHEA VIRUS TYPE 2 IN CATTLE.

R. Liang, J.V. van den Hurk, A. Landi, D. Deregt, L.A. Babiuk and S. van Drunen Littel-van den Hurk, Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Canada.

3:20 – 3:40 PM
M14 - NOVEL PLANT VIRUS-BASED VACCINE INDUCES PROTECTIVE CTL MEDIATED IMMUNITY THROUGH EFFICIENT DENDRITIC CELL MATURATION.

Patrick Lacasse*, Jérôme Denis†, Réjean Lapointe‡, Denis Leclerc† et Alain Lamarre* * Immunovirology Laboratory, INRS-Institut Armand-Frappier, Laval, Qc, Canada. † Centre de Recherche en Infectiologie, Pavillon CHUL, Université Laval, Québec, Qc, Canada ‡ Centre de Recherche, CHUM, Hôpital Notre-Dame, Université de Montréal and Institut du Cancer de Montréal, Montréal, Qc, Canada.

3:40 – 4:00 PM
M15 - SIGNIFICANT ENHANCEMENT OF SPECIFIC CELLULAR IMMUNE RESPONSE BUT SUBSTANTIAL SUPPRESSION OF MUCOSAL ANTIBODY RESPONSES IN BALB/C MICE ADMINISTRATED WITH ADENOVIRUS TARGETED TO CD40 (+) CELLS.

Caroline Gravel1, Deqi Huang1, Alexander V Pereboev2, Nikolay Korokhov2, Runtao He3, Bozena Jaentschke1, Louise Larocque1, William Casley1, Michelle Lemieux1, David T. Curiel2, Wanxue Chen4 and Xuguang Li1,5 1. Centre for Biologics Research, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, ON, Canada 2. Gene Therapy Centre, University of Alabama at Birmingham, Birmingham, AL, USA 3. National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada 4. National Research Council, Ottawa, On, Canada 5. Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, On, Canada.

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4:30 – 4: 50 PM
M16 - IMMUNOGENICITY OF A GIARDIA LAMBLIA TRANSMISSION-BLOCKING DNA VACCINE DELIVERED BY SALMONELLA TYPHIMURIUM (STM1 STRAIN) TO THE INTESTINAL MUCOSAL IMMUNE SYSTEM.

Aws Abdul-Wahid and G. Faubert. Institute of Parasitology, McGill University, Ste-Anne-de-Bellevue, Canada.

4:50 – 5:10 PM
M17 - ANTI-APOPTOTIC MOLECULE M11L ENHANCES IMMUNOGENICITY OF HIV DNA VACCINE IN MICE.

Jin Su, Grant McFadden and Gregory Dekaban, BioTherapeutics Research Group, Robarts Research Institute, London, ON, Canada.

5:10- 5:30 PM
M18 - CONSIDERATIONS IN VACCINE DRUG DEVELOPMENT FOR PRE-MARKET REGULATORY REQUIREMENTS.

Harold Rode, Centre for Biologics Evaluation, Biologics and Genetic Therapies Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ontario.

2:30 - 3:00 PM
Cytokines and viruses: signaling for supremacy.
Chair: Eleanor Fish, University of Toronto, Toronto, ON

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3:00 – 3:20 PM
M19 - GAMMA-CHAIN RECEPTOR CYTOKINES DOWN-REGULATE IL-7 RECEPTOR-ALPHA (CD127) EXPRESS-ION ON CD8+ T-CELLS AND DIFFERENTIALLY AFFECT CELL CYCLING OF ACTIVATED CD8+CD127+ AND CD8+CD127- CELLS.

Crawley AM., Katz T., Parato K., Angel JB. Ottawa Health Research Institute, Ottawa, Ontario. CANADA.

3:20 – 3:40 PM
M20 - THE ABILITY OF VERO CELLS TO DIFFERENTIALLY RESPOND TO VIRUS-DERIVED STIMULI DEPENDS ON PROTEIN ABUNDANCE AND A NOVEL CELLULAR COMPONENT.

Tracy Chew, Meaghan Hancock, and Karen L. Mossman, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

3:40 – 4:00 PM
M21 - CHARACTERIZATION OF INTRACELLULAR SIGNALLING COMPONENTS INVOLVED IN SEPSIS.

Tyler Kirwan, Danielle Brabant, Paul Michael, Marisa Tessier, Marija Tonnos, Shuhung Kung, Abdelwahab Omri, Chilakamarti V. Ramana, Anand Kumar, Joseph E. Parrillo and Aseem Kumar, Department of Chemistry and Biochemistry and the Biomolecular Sciences Programme, Laurentian University, Sudbury, ON, Canada.

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4:30 – 4:50 PM
M22 - HUMAN SEPTIC SERA INDUCES DEATH RECEPTOR MEDIATED APOPTOSIS IN HUMAN FIBROBLASTS.

Danielle Brabant, Paul Michael, Marija Tonnos, Marisa Tessier, Shuhung Kung, Tyler Kirwan, Abdelwahab Omri, Chilakamarti V. Ramana, Joseph E. Parrillo, Anand Kumar and Aseem Kumar, Department of Chemistry and Biochemistry and the Biomolecular Sciences Programme, Laurentian University, Sudbury, ON, Canada.

4:50 - 5:10 PM
M23 - STUDY OF THE SUSCEPTIBILITY OF TWO INBRED MOUSE STRAINS TO STREPTOCOCCUS SUIS SEROTYPE 2 INFECTION.

Maria de la Cruz Dominguez-Punaro1, Mariela Segura2, Danuta Radzioch 2, Serge Rivest 3 and Marcelo Gottschalk1. 1GREMIP/CRIP, Faculté médecine vétérinaire, Université de Montréal, St-Hyacinthe, QC 2McGill University Health Centre Research Institute, Montréal, QC 3Laboratory Molecular Endocrinology, CHUL, St-Foy, QC.

5:10 – 5:30 PM
M24 - LIGHT IS CRITICAL FOR IL-12 PRODUCTION BY ANTIGEN PRESENTING CELLS, TH1 CELL DEVELOPMENT AND RESISTANCE TO LEISHMANIA MAJOR.

Guilian Xu, Dong Liu, Ifeoma Okwor, Sam Kung, YangXin Fu* and Jude E Uzonna, Department of Immunology, University of Manitoba, Winnipeg, *Department of Pathology, University of Chicago, IL, USA. Source of Research Funds: CIHR and MHRC.